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The Government may have certain rights in the invention. While anti-TNF treatments have been tremendously successful, they Chnce r0mn not produce Chnce r0mn clinical responses in all patients who receive them. Identification of a patients as being likely or unlikely to respond to anti-TNF treatment Chnce r0mn a critical for optimal patient management.

Patients exhibiting biomarkers suggesting they are unlikely to respond to anti-TNF treatment can be steered to other therapies immediately i. For example, the expression level of one or more of the genes depicted in Table 1 or the presence of one or more of the single nucleotide polymorphisms depicted in Tables or 13 can predict the likelihood that a given subject will or will not respond to an anti-TNF therapy.

The biomarkers, compositions, and methods described herein are thus useful in selecting appropriate treatment Chnce r0mn e. In one aspect, the disclosure provides a method of treating an immune disorder, which method includes the step of administering to a subject in need thereof an effective amount of a therapy comprising an anti-TNF agent, wherein the subject has been identified as having at least one e. In another aspect, the disclosure provides a method of treating an immune Chnce r0mn, which method includes the step of administering to a subject in need thereof an effective amount of a therapy comprising Chnce r0mn non-anti-TNF agent, wherein the subject has been identified as having at least one e.

In some embodiments of either of the methods above, the subject has been identified as having elevated or reduced expression levels, as compared to a healthy individual, of at least two e. The at least five genes can include, e. The at least eight genes can include, e. The at least eight genes can consist of, or include, e. The at least 24 genes can consist of, or include, e.

In another aspect, the disclosure features a method of predicting the response of a subject to a therapy comprising an anti-TNF agent. The method includes the steps of: The RNA or protein expression of the one Chnce r0mn more genes can be measured. The RNA expression level of the one or more genes can be measured using, e.

The method can further include Chnce r0mn the therapy comprising an anti-TNF agent to the subject. The record can be created, e. The method can further include administering the therapy comprising a non-anti-TNF agent to the subject. The methods described herein can include measuring the expression level of at least two e. In another aspect, the disclosure provides a method of predicting the response of a subject to therapy comprising an anti-TNF agent, which method includes the step of assessing the expression level e.

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In some embodiments, the method can include determining that the expression level of one or more e. In some Chnce r0mn, the methods include, after predicting that the subject will respond to the anti-TNF therapy, administering to the subject the anti-TNF therapy.

In some embodiments, the methods include, after predicting that the subject will not respond to the anti-TNF therapy, Chnce r0mn to the subject a non-anti-TNF therapy. In yet another aspect, the disclosure features a method of treating an immune disorder. The method includes the step of administering to a subject in need thereof an effective amount of a therapy comprising an anti-TNF agent, wherein the subject has been identified as having one or more e.

In another aspect, the disclosure features a method of treating an immune disorder, which method includes the step of administering to a subject in need thereof an effective amount of a therapy comprising a non-anti-TNF agent, wherein the subject has been identified Chnce r0mn having one or more e.


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